Horvath’s clock proved a very clear relationship between this methylation?—?both gained and lost?—?and the chronological age of humans, or as Horvath puts it, “the number on your passport.” He also believes it bears some relationship to biological age, the very definition of which is so hotly debated among biologists that Horvath compares its vagueness to … Continue reading Is Horvath’s Clock the Smoking Gun of Biological Aging?
Barzilai’s big plan isn’t necessarily less quixotic than those being dreamed up at Silicon Valley biotechs. It’s just quixotic in a completely different way. Rather than trying to develop a wildly expensive, highly speculative therapy that will likely only benefit the billionaire-demigod set, Barzilai wants to convince the FDA to put its seal of approval on … Continue reading Forget the blood of teens. This pill promises to extend life for a nickel a pop
A critical aspect of fasting — which is different from simply restricting calories — is that the body undergoes a metabolic switch from using glucose to using ketones as fuel, a result of the depletion of liver energy stores and the mobilization of fat. The presence of ketones in the blood signifies that on the … Continue reading Is fasting the fountain of youth?
Senescent cells were first described in the late 1950s but remained largely a curiosity until 2008 when their dark nature was revealed by Judith Campisi and others. She found that the cells secrete a cocktail of foul factors, which poison the surrounding tissue. Niedernhofer likens them to that bad strawberry in the punnet, rotting everything … Continue reading Want to live forever? Flush out your zombie cells
The amount of data you slough off everyday—in lab tests, medical images, genetic profiles, liquid biopsies, electrocardiograms, to name just a few—is overwhelming by itself. Throw in the stuff from medical claims, clinical trials, prescriptions, academic research, and more, and the yield is something on the order of 750 quadrillion bytes every day—or some 30% … Continue reading Tech’s next big wave: big data meets biology
Aging is a natural process that occurs in all humans as cells decline. One scientific explanation for aging relates to the accumulation of “senescent” cells in tissues and organs. Scientists have successfully reversed the aging of human cells in lab conditions. The research could provide answers about how to treat age-related disease.
Autophagy helps to clear damaged cells from the body, including senescent cells that serve no functional purpose but still linger inside tissues and organs. The reason it’s so important to remove senescent and damaged cells is because they can trigger inflammatory pathways and contribute to various diseases. In fact, autophagy is so beneficial that it’s now being called a … Continue reading Benefits of autophagy, plus how to induce it.
Blockchain is not meant for storage of large data sets. Blockchain is not an analytics platform. Blockchain has very slow transactional performance. However, as a tamperproof public ledger, blockchain is ideal for proof of work. Blockchain is highly resilient. In the future we might see blockchain as a component of a system in which patients … Continue reading Will blockchain transform healthcare?
One of the things people tend to worry about in life is the fact that it will come to an end. Even if you avoid being hit by a bus, or mauled by a pack of angry football fans, you’re going to die eventually. As it turns out not that many British people would change … Continue reading Who wants to live forever? Only one in six brits, according to a new poll
New York Times
A growing body of research suggests that our bodies function optimally when we align our eating patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Studies show that chronically disrupting this rhythm — by eating late meals or nibbling … Continue reading When we eat, or don’t eat, may be critical for health
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